Registration for incomplete exponential family functional data.

- Authors: Julia Wrobel, Alexander Bauer
- License: MIT. See the LICENSE file for details
- Version: 2.1

Functional data analysis is a set of tools for understanding patterns and variability in data where the basic unit of observation is a curve measured over some domain such as time or space. An example is an accelerometer study where intensity of physical activity was measured at each minute over 24 hours for 50 subjects. The data will contain 50 curves, where each curve is the 24-hour activity profile for a particular subject.

Classic functional data analysis assumes that each curve is continuous or comes from a Gaussian distribution. However, applications with exponential family functional data – curves that arise from any exponential family distribution, and have a smooth latent mean – are increasingly common. For example, take the accelerometer data just mentioned, but assume researchers are interested in *sedentary behavior* instead of *activity intensity*. At each minute over 24 hours they collect a binary measurement that indicates whether a subject was active or inactive (sedentary). Now we have a *binary curve* for each subject – a trajectory where each time point can take on a value of 0 or 1. We assume the binary curve has a smooth latent mean, which in this case is interpreted as the probability of being active at each minute over 24 hours. This is a example of exponential family functional data.

Often in a functional dataset curves have similar underlying patterns but the main features of each curve, such as the minimum and maximum, have shifts such that the data appear misaligned. This misalignment can obscure patterns shared across curves and produce messy summary statistics. Registration methods reduce variability in functional data and clarify underlying patterns by aligning curves.

This package implements statistical methods for registering exponential family functional data. The basic methods are described in more detail in our paper and were further adapted to (potentially) incomplete curve settings where (some) curves are not observed from the very beginning and/or until the very end of the common domain. For details on the incomplete curve methodology and how to use it see the corresponding package vignette. Instructions for installing the software and using it to register simulated binary data are provided below.

To install from `CRAN`

, please use:

`install.packages("registr")`

To install the latest version directly from Github, please use:

```
install.packages("devtools")
devtools::install_github("julia-wrobel/registr")
```

The `registr`

package includes vignettes with more details on package use and functionality. To install the latest version and pull up the vignettes please use:

```
devtools::install_github("julia-wrobel/registr", build_vignettes = TRUE)
vignette(package = "registr")
```

This example registers simulated binary data. More details on the use of the package can be found in the vignettes mentioned above.

The code below uses `registr::simulate_unregistered_curves()`

to simulate curves for 100 subjects with 200 timepoints each, observed over domain (0, 1). All curves have similar structure but the location of the peak is shifted. On the observed domain *t*^{*} the curves are unregistered (misaligned). On the domain *t* the curves are registered (aligned).

```
library(registr)
registration_data = simulate_unregistered_curves(I = 100, D = 200, seed = 2018)
```

The plot below shows the unregistered curves and registered curves.

Continuously observed curves are shown above in order to illustrate the misalignment problem and our simulated data; the simulated dataset also includes binary values which have been generated by using these continuous curves as probabilities. The unregistered and registered binary curves for two subjects are shown below.

Our software registers curves by estimating *t*. For this we use the function `registration_fpca()`

.

```
binary_registration = register_fpca(Y = registration_data, family = "binomial",
Kt = 6, Kh = 4, npc = 1)
## Running initial registration step
## current iteration: 1
## Running final FPCA step
```

The plot below shows unregistered, true registered, and estimated registered binary curves for two subjects after fitting our method.

If you like our software, please cite it in your work! To cite the latest `CRAN`

version of the package with `BibTeX`

, use

```
@Manual{,
title = {registr: Registration for Exponential Family Functional Data},
author = {Julia Wrobel and Erin McDonnell and Jeff Goldsmith},
year = {2020},
note = {R package version 1.0.0},
url = {https://CRAN.R-project.org/package=registr},
}
```

To cite the Journal of Open Source Software paper, use

If you find small bugs, larger issues, or have suggestions, please file them using the issue tracker or email the maintainer at julia.wrobel@cuanschutz.edu. Contributions (via pull requests or otherwise) are welcome.